Probiotic disputes – the promotion of probiotic strains

A continuation of the article on probiotics and their beneficial effects on the body.

Probiotic controversies – part 2 post image

The benefits of probiotics for gut microbiome health

Your gut health and the balance of your microbiome are linked in various ways to every aspect of your health. Spore-based probiotics, such as those contained in Microbiome Labs’ MegaSporeBiotic™, support the gut microbiome in several different ways:

Increased diversity of gut microorganisms and gut restoration

Thanks to their robust protective coating, the unique blend of Bacillus strains contained in the MegaSporeBiotic™ probiotic is able to survive the hazardous journey through your digestive system – allowing them to reach your large intestine intact. Once they reach their destination, these dormant spores can transform into their active forms and begin to replicate and colonise your gut – restoring your gut flora to function optimally.

This increased diversity of microorganisms is one of the keys to creating a balanced and healthy ‘ecosystem’ amongst the microorganisms that inhabit your gut. But this is not the only way in which spore-forming probiotics benefit gut health.

Promotion of other beneficial probiotic strains:

Spore-based probiotics are also well known for their ability to increase levels of beneficial metabolites, including:

  • short-chain fatty acids (SCFAs) – SCFAs are the main source of energy for intestinal epithelial cells. They support the repair and regeneration of the intestinal barrier;
  • lactic acid – it has antibacterial properties and serves as a substrate for the production of SCFAs;
  • conjugated linoleic acid (CLA) – this acid helps prevent obesity, allergies and asthma, and improves the overall functioning of the immune system;
  • bacteriocins – natural ‘antibiotics’ that reduce the population of pathogenic bacteria in the gut;

All these metabolites, in turn, support and promote other probiotic strains present in your gut. This phenomenon of ‘probiotics promoting probiotics’ creates a virtuous cycle that further increases microbial diversity and fosters a thriving gut microbial ecosystem.

A strengthened and impermeable intestinal barrier

The MegaSporeBiotic™ probiotic blend aids in the production and synthesis of vitamins and other compounds (such as SCFAs) that play a role in maintaining the integrity of the intestinal barrier. By increasing the production of these key compounds, spore-based probiotics help to ‘strengthen’ the intestinal barrier and reduce intestinal permeability – enabling the gut to retain potentially harmful toxins and pathogens until they are properly excreted.

The health benefits of the spore-based probiotic MegaSporeBiotic™

Although it is clear that MegaSporeBiotic™ has an extremely beneficial effect on gut health, these health benefits go much deeper. Research has shown that the additional benefits of MegaSporeBiotic™ include:

1. Lowering triglyceride levels:

Studies have shown that daily supplementation with MegaSporeBiotic™ can significantly reduce elevated triglyceride levels – both in the short term, immediately after consuming a meal that raises triglyceride levels, and in the long term. These findings may have significant and exciting implications for managing chronic conditions that affect triglyceride levels.

2. Alleviation of leaky gut syndrome (LGS) symptoms:

Increased intestinal permeability, also known as leaky gut syndrome, can result in endotoxins (toxic compounds found in bacteria) entering the bloodstream – triggering the release of pro-inflammatory cytokines and subsequently increasing overall inflammation. Supplementation with MegaSporeBiotic™ probiotics significantly improves the integrity of the intestinal barrier, whilst substantially reducing markers of inflammation, endotoxin levels and overall inflammation.

3. Protection against liver damage: 

Paracetamol (APAP) – one of the most widely used painkillers and fever-reducers in the world – is also a leading cause of liver toxicity and liver damage. Studies have shown that MegaSporeBiotic™ has significant hepatoprotective properties – reducing levels of liver-damaging compounds and protecting the liver from damage caused by increased or prolonged use of paracetamol.

Sources:

  1. Treatment with a spore-based probiotic containing five strains of Bacillus induced changes in the metabolic activity and community composition of the gut microbiota in a SHIME® model of the human gastrointestinal system – ScienceDirect
  2. A synbiotic formulation containing spore-forming Bacillus strains and a prebiotic fibre blend consistently enhanced metabolic activity by modulating the gut microbiome in vitro – ScienceDirect
  3. Bacillus spp. Spores—A Promising Treatment Option for Patients with Irritable Bowel Syndrome – PMC (nih.gov)
  4. Efficacy of Spore-Forming Bacilli Supplementation in Patients with Mild to Moderate Elevation of Triglycerides: A 12-week, Randomised, Double-blind, Placebo-controlled Trial – PubMed (nih.gov)
  5. Oral spore-based probiotic supplementation was associated with a reduced incidence of postprandial dietary endotoxins, triglycerides, and biomarkers of disease risk – PMC (nih.gov)
  6. Probiotic Bacillus Spores Protect Against Acetaminophen-Induced Acute Liver Injury in Rats – PubMed (nih.gov)